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New ‘Trojan Horse’ drug could super-charge weight loss and retrain the brain, study finds
Weight loss injections seem to be a hot topic online right now, as lots of people are using medication like Ozempic to tackle obesity and blood sugar levels. A study has found that a new ‘Trojan Horse’ drug could aid weight loss even further and retrain the brain after pounds are shed.
The ‘Trojan Horse’ treatment has been tested on mice and used GLP-1 weight loss jab technology to sneak in molecules that help train the brain to accept weight loss. It comes after the success and hype around weight loss injections, such as Ozempic and Mounjaro. Ozempic has been around for the best part of two decades, helping those diagnosed with diabetes with their insulin and blood sugar levels. It became widespread knowledge of its effectiveness to help reduce appetite and reduce waistbands after it was in high demand in Hollywood from 2020.
New ‘Trojan Horse’ drug could super-charge weight loss
Medical News Today reveals a new study used a�’Trojan horse’ GLP-1 drug to smuggle neuroplasticity molecules into the brains of mice, which doubled weight loss.
Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene that is expressed in these cells.
Researchers say this experimental drug increased neuroplasticity in the brain to facilitate weight loss.
The findings suggest that GLP-1 drugs could leak through the blood-brain barrier as they carry these plasticity-promoting molecules alongside the hormone.
This health method used technology similar to Ozempic and Wegovy, referred to as�glucagon-like peptide-1 receptor agonists�(GLP-1 RA).
The findings theorize these drugs smuggle neuroplasticity molecules into rodents’ brains to make them more responsive to weight loss, and the brain’s ability to change or adapt. If this is the case for humans, it could mean physicians can prescribe lower doses and reduce some of the harsher symptoms with the medications currently on the market.
Ozempic, which uses semaglutide like Wegovy, is an injection that was originally designed for people with type 2 diabetes but is now being used to tackle obesity.
Study finds injectable weight loss drug can retrain the brain
The drug works by mimicking a hormone produced naturally by the gut after a meal to slow digestion, decrease hunger pangs, and shed body weight.
The study corresponding author, Christoffer Clemmensen, PhD, says the new drug could be used alongside another to retrain the neural pathways and connections in the brain to help it adjust to the new lower number on the scale.
For anyone who manages to shed a lot of weight, it can be an uphill battle as the body tries to get back to, or adjust, to a new ‘set point’ – the base level. As our bodies, evolutionary wise, are concerned we need to survive, losing the pounds can have the opposite effect as it thinks there isn’t enough food to sustain it. This can lead to more hunger cries from the stomach, metabolism crashing and being reduced so you burn fewer calories, and craving high calorie foods that would sustain your energy, like carbohydrates.
The study, published in Nature, was conducted by researchers with the Novo Nordisk Foundation Center for Basic Metabolic Research. Novo Nordisk manufactures Wegovy and Ozempic pens.
SCARY SIDE EFFECTS: Plastic surgeon explains common side effects you will get while taking Ozempic
